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KMID : 0861020120270050099
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Korea Journal of Herbology
2012 Volume.27 No. 5 p.99 ~ p.107
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Effects of CJB Water Extract on Obesity-Related Factors in Hypothalamus of Rats Fed High-Fat Diet
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Hwang Jeong-Soo
Suk Jang-Mi
Choi Hye-Min
Shin In-Soon
Hwang Su-Jung
Park Ji-Young
Kim Sung-Ok
Seo Bu-Il
Kim Mi-Ryeo
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Abstract
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Objectives: This study was conducted to investigate the anti-obesity effects of mixed water extract of Plantaginis Semen & Poria (CJB) on obese rats induced with high fat diet.
Methods: Male Sprague-Dawley rats were divided into three groups; Normal group, high-fat (HF) group, HF+CJB(100 mg/kg, P.O.) for 8 weeks. The body weight, food intake and weights of adipose tissues were measured, respectively. Lipid profiles in serum were analyzed by automatic analyzer of blood. Obese marker proteins and the changes of NPY and LR immunoreactivities in hypothalamus were analyzed by Western blot and immunohistochemistry.
Results: CJB significantly reduced body weight, food intake, adipose tissue weights compared to HF group. Serum triglyceride and total cholesterol were significantly higher in HF group than in Normal group however, CJB significantly lowered those of HF group. HDL-cholesterol level in CJB groups was elevated compared to HF group. The pAMPK in hypothalamus were decreased in that of HF group and that of CJB group decreased. Inversely, ACC was increased in HF group and that of CJB groups decrease. Expression of in hypothalamus was increased by CJB treatment. However, levels in CJB group were decreased compared to HF group. The expressions of NPY and LR in PVN and ARC of hypothalamus were decreased in CJB group, respectively.
Conclusions: Administration of CJB can play anti-obesity through regulations of NPY and LR activities and obesity marker proteins in obese rat’s hypothalamus.
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KEYWORD
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Mixed water extract of Plantaginis Semen & Poria (CJB), high fat diet, lipid profiles, hypothalamus, anti-obesity
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